研究・業績
教室業績集
業績（2019）
英文論文
How Cervical Reconstruction Surgery Affects Global Spinal Alignment
Mizutani J, Strom R, Abumi K, Endo K, Ishii K, Yagi M, Tay B, Deviren V, Ames C.
Neurosurgery 84 : 898-907, 2019
Biomechanical and Anatomical Validity of the Short Posterior Arch Screw
Mizutani J, Inoue N, Otsuka Y, Furuya A, Orias AAE, Otsuka T.
Neurospine 16 : 347-353, 2019
Altered shoulder kinematics using a new model for multiple dislocations-induced Bankart lesions
Yoshida M, Takenaga T, Chan CK, Musahl V, Lin A, Debski RE.
Clin Biomed（Bristol, Avon） 70 : 131-136, 2019
Superior clavicle drilling points and fluoroscopic inclination for anatomic coracoclavicular ligament reconstruction: acadaveric study
Takenaga T, Yoshida M, Debski RE, Fu FH, Musahl V, Lin A.
Knee Surg Sports Traumatol Arthrosc 27 : 3813-3820, 2019
Relationship between bilateral humeral retroversion angle and starting baseball age in skeletally mature baseballplayers -existence of watershed age-
Takenaga T, Goto H, Tsuchiya A, Yoshida M, Fukuyoshi M, Nakagawa H, Takeuchi S, Takaba K, Sugimoto K
Journal of Shoulder Elbow Surg 28 : 847-853, 2019
Preoperative sonographic measurement can accurately predict quadrupled hamstring tendon graft diameter for ACL reconstruction
Takenaga T, Yoshida M, Albers M, Nagai K, Nakamura T, Fu FH, Onishi K
Knee Surg Sports Traumatol Arthrosc 27 : 797-804, 2019
The differences of humeral torsion angle and the glenohumeral rotation angles between young right-handed and lefthanded pitchers
Takeuchi S, Yoshida M, Sugimoto K, Tsuchiya A, Takenaga T, Goto H
J Shoulder Elbow Surg 28 : 678-684, 2019
Ultrasonographic assessment of femoral torsion angle based on tilting angles of femoral neck and condylar axis
Takeuchi S, Goto H, Iguchi H, Watanabe N, Osaga S, Murakami H, Yoshida M
Ultrasound Med Biol 45 : 1970-1976, 2019
Radiographic analysis of subclinical appearances of the hip joint among patients with labral tears
Aiba H, Watanabe N, Fukuoka M, Wada I, Murakami H
J Orthop Surg Res 14 : 369, 2019
Treatment of a Malignant Soft Tissue Tumor Arising in the Vicinity of the Sciatic Nerve with an In-Situ Preparation Technique and Intensive Multidisciplinary Therapy
Aiba H, Hayashi K, Yamada S, Okamoto H, Kimura H, Miwa S, Inatomi H, Otsuka T, Murakami H
Cancers（ Basel） 11 : 506, 2019
Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine
Kobayashi M, Kato S, Murakami H, Demura S, Yoshioka K, Yonezawa N, Takahashi N, Shimizu T, Tsuchiya H
Orthopedics 42 : e131-e134, 2019
Dose Reduction Protocol for Full Spine X-ray Examination Using Copper Filters in Patients with Adolescent Idiopathic Scoliosis
Minehiro K, Demura S, Ichikawa K, Sasagawa T, Takahashi N, Minami S, Murakami H, Tsuchiya H
Spine（ Phila Pa 1976） 44 : 203-210, 2019
Kidney and thyroid cancer-specific treatment algorithm for spinal metastases: a validation study
Kato S, Murakami H, Demura S, Yoshioka K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Tsuchiya H
World Neurosurg 122 : e1305-e1311, 2019
Lung metastases regression with increased CD8+ T lymphocyte infiltration following preoperative spinal embolization and total en bloc spondylectomy using tumor-bearing frozen autograft in a patient with spinal metastatic leiomyosarcoma
Yonezawa N, Murakami H, Sangsin A, Mizukoshi E, Tsuchiya H
Eur Spine J 28（Suppl 2） : 41-50, 2019
Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: what is the impact of Parkinson's disease on surgical outcome?
Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Izumi T, Hirano T, Endo N, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K
BMC Musculoskelet Disord 20 : 103, 2019
The Large Individual Differences in the Range of Hip Joint Motion Rather Than Lumbar Spine Motion Affect Dynamic Spinopelvic Rhythm
Yoshioka K, Murakami H, Demura S, Kato S, Kawashima H, Sanada S, Tsuchiya H
Spine Surg Relat Res 3 : 255-260, 2019
Motor and Sensory Impairments of the Lower Extremities After L2 Nerve Root Transection During Total en Bloc Spondylectomy
Kato S, Murakami H, Demura S, Ota T, Takahashi N, Yoshioka K, Shinmura K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H
Spine（ Phila Pa 1976） 44 : 1129-1136, 2019
Morphologic changes after denosumab therapy in patients with giant cell tumor of the spine: Report of four cases and a review of the literature
Yonezawa N, Murakami H, Demura S, Kato S, Yoshioka K, Takeuchi A, Shinmura K, Yokogawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Tsuchiya H
World Neurosurg 127 : 38-46, 2019
Efficacy of vertebral cryoablation and immunotherapy in a patient with metastatic renal cell carcinoma: a case report
Sangsin A, Murakami H, Shimizu T, Kato S, Tsuchiya H
J Med Case Rep 13 : 96, 2019
Risk Factors for Proximal Junctional Fracture Following Fusion Surgery for Osteoporotic Vertebral Collapse with Delayed Neurological Deficits: A Retrospective Cohort Study of 403 Patients
Tamai K, Terai H, Suzuki A, Nakamura H, Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Izumi T, Hirano T, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K
Spine Surg Relat Res 3 : 171-177, 2019
Fluoroscopy-assisted posterior percutaneous reduction for the management of unilateral cervical facet dislocations after unsuccessful closed reduction: A case report
Shimizu T, Yoshioka K, Murakami H, Demura S, Kato S, Yokogawa N, Oku N, Kitagawa R, Tsuchiya H
Int J Surg Case Rep 58 : 212-215, 2019
Abdominal trunk muscle weakness and its association with chronic low back pain and risk of falling in older women
Kato S, Murakami H, Demura S, Yoshioka K, Shinmura K, Yokogawa N, Igarashi T, Yonezawa N, Shimizu T, Tsuchiya H
BMC Musculoskelet Disord 20 : 273, 2019
Utility of bone SPECT/CT to identify the primary cause of pain in elderly patients with degenerative lumbar spine disease
Kato S, Demura S, Matsubara H, Inaki A, Shinmura K, Yokogawa N, Murakami H, Kinuya S, Tsuchiya H
J Orthop Surg Res 14 : 185, 2019
Surgical metastasectomy for renal cell carcinoma: which patients are the real candidates for surgery?
Kato S, Demura S, Murakami H, Tsuchiya H
Ann Transl Med 7（Suppl 8）: S273, 2019
Cost-effectiveness analysis of the pharmacological management of chronic low back pain with four leading drugs
Kaito T, Matsuyama Y, Yamashita T, Kawakami M, Takahashi K, Yoshida M, Imagama S, Ohtori S, Taguchi T, Haro H, Taneichi H, Yamazaki M, Inoue G, Nishida K, Yamada H, Kabata D, Shintani A, Iwasaki M, Ito M, Miyakoshi N, Murakami H, Yonenobu K, Takura T, Mochida J; Project Committee of the Japanese Society for Spine Surgery and Related Research（ JSSR）
J Orthop Sci 24 : 805-811, 2019
Surgical outcomes of spinal fusion for osteoporotic vertebral fracture in the thoracolumbar spine: Comprehensive evaluations of 5 typical surgical fusion techniques
Watanabe K, Katsumi K, Ohashi M, Shibuya Y, Hirano T, Endo N, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Matsuoka Y, Suzuki H, Nishimura H, Terai H, Tamai K, Tagami A, Yamada S, Adachi S, Yoshii T, Ushio S, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Nakano A, Sakai D, Nukaga T, Ikegami S, Shimizu M, Futatsugi T, Ohtori S, Furuya T, Orita S, Imagama S, Ando K, Kobayashi K, Kiyasu K, Murakami H, Yoshioka K, Seki S, Hongo M, Kakutani K, Yurube T, Aoki Y, Oshima M, Takahata M, Iwata A, Endo H, Abe T, Tsukanishi T, Nakanishi K, Watanabe K, Hikata T, Suzuki S, Isogai N, Okada E, Funao H, Ueda S, Shiono Y, Nojiri K, Hosogane N, Ishii K
J Orthop Sci 24 : 1020-1026, 2019
Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study
Sakai Y, Kaito T, Takenaka S, Yamashita T, Makino T, Hosogane N, Nojiri K, Suzuki S, Okada E, Watanabe K, Funao H, Isogai N, Ueda S, Hikata T, Shiono Y, Watanabe K, Katsumi K, Fujiwara H, Nagamoto Y, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Orita S, Furuya T, Yoshii T, Ushio S, Inoue G, Miyagi M, Saito W, Imagama S, Ando K, Sakai D, Nukaga T, Kiyasu K, Kimura A, Inoue H, Nakano A, Harimaya K, Doi T, Kawaguchi K, Yokoyama N, Oishi H, Ikegami S, Futatsugi T, Shimizu M, Kakutani K, Yurube T, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Seki S, Murakami H, Yoshioka K, Endo H, Hongo M, Nakanishi K, Abe T, Tsukanishi T, Ishii K
J Orthop Sci 24 : 985-990, 2019
Surgical Treatment of Osteoporotic Vertebral Fracture with Neurological Deficit-A Nationwide Multicenter Study in Japan
Hosogane N, Nojiri K, Suzuki S, Funao H, Okada E, Isogai N, Ueda S, Hikata T, Shiono Y, Watanabe K, Watanabe K, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Orita S, Furuya T, Yoshii T, Ushio S, Inoue G, Miyagi M, Saito W, Imagama S, Ando K, Sakai D, Nukaga T, Kiyasu K, Kimura A, Inoue H, Nakano A, Harimaya K, Kawaguchi K, Yokoyama N, Oishi H, Doi T, Ikegami S, Shimizu M, Futatsugi T, Kakutani K, Yurube T, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Seki S, Murakami H, Yoshioka K, Endo H, Hongo M, Nakanishi K, Abe T, Tsukanishi T, Ishii K
Spine Surg Relat Res 3 : 361-367, 2019
Differences in postual stability and dynamic visual acuity among healthy young adults in relation to sports activity: a cross sectional study
Koide Y, Ueki Y, Asai Y, Morimoto H, Asai H, Johnson EG, Lohman EB, Sakuma E, Mizutani J, Ueki T, Wada I
J Phys Ther Sci 31 : 53-56, 2019
Outcomes of Fusions from the cervical spine to the pelvis
Iyer S, Kim HJ, Theologis A, Nemani VM, Albert TJ, Lenke LG, Burch S, Boachie-Adjei O, Deviren V, Protopsaltis TS, Smith JS, Scheer JK, Mizutani J, Kleinberg EO, Ames CP.
Global Spine J 9 : 6-13, 2019
Objective measures of physical activity in patients with chronic unilateral vestibular hypofunction, and its relationship to handicap, anxiety and postural stability
Morimoto H, Asai Y, Johnson EG, Koide Y, Niki J, Sakai S, Nakayama M, Kabaya K, Fukui A, Mizutani Y, Mizutani T, Ueki Y, Mizutani J, Ueki T, Wada I
Auris Nasus Larynx 46 : 70-77, 2019Distribution of solitary and multiple enchondromas of the Hand
Miwa S, Okamoto H, Yamada S, Kawaguchi Y, Endo K, Aiba H, Hayashi K, Kimura H, Sekiya I, Otsuka T, Tsuchiya H In Vivo 33 : 2235-2240, 2019
Exploring the validation of a Japanese version of the International Hip Outcome Tool 12: Reliability, validity, and responsiveness
Watanabe N, Murakami S, Uchida S, Tateishi S, Ohara H, Yamamoto Y, Kojima T, JAHORN.J Orthop Sci 24 : 652-657, 2019
Japanese version of the international PROMs "Vail Hip Score": Reliability, validity, and responsiveness according to the COSMIN checklist
Watanabe N, Murakami S, Uchida S, Tateishi S, Ohara H, Yamamoto Y, Kojima T, JAHORN.
J Orthop Sci 24 : 447-451, 2019
A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model
Sheldrick K, Chamoli U, Masuda K, Miyazaki S, Kato K, Diwan AD.
JOR Spine 2 : e1060, 2019
Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase
Kim W, Tokuda H, Kawabata T, Fujita K, Sakai G, Nakashima D, Tachi J, Kuroyanagi G, Matsushima-Nishiwaki R, Tanabe K, Otsuka T, Iida H, Kozawa O
Prostaglandins Other Lipid Mediat 143 : 106327, 2019
IL6 receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice
Kamiya N, Kuroyanagi G, Aruwajoye O, Kim HKW
Osteoarthritis Cartilage 27 : 326-335, 2019
HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase.
Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O Biomed Res 40 : 169-178, 2019
A prospective clinical trial to assess the accuracy of an MRI-based patient-specific acetabular instrument guide in total hip arthroplasty.
Inoue D, Kabata T, Kimura H, Tsuchiya H.
Eur J Orthop Surg Traumatol 29: 65-71, 2019
The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Higuchi T, Kawaguchi K, Miyake K, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Nelson SD, Dry SM, Li Y, Chawla SP, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM.
Biomed Pharmacother 111 :835-840, 2019
Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice.
Higuchi T, Oshiro H, Zhang Z, Miyake K, Sugisawa N, Katsuya Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Zhao M, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Transl Oncol 12: 640-645, 2019
Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model.
Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Cancer Lett 451: 122-127, 2019
Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Cancer Chemother Pharmacol 83: 1075-1082, 2019
Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model.
Higuchi T, Miyake K, Oshiro H, Sugisawa N, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Biochem Biophys Res Commun 513: 326-331, 2019
Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM.
Tissue Cell 58: 107-111, 2019
The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Transl Oncol 12: 1257-1263, 2019
Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Anticancer Res 39: 4079-4084, 2019
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Higuchi T, Oshiro H, Miyake K, Sugisawa N, Han Q, Tan Y, Park J, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Chawla SP, Singh SR, Tsuchiya H, Hoffman RM.
Anticancer Res 39: 4653-4657, 2019
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Belt P, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Anticancer Res 39: 4781-4786, 2019
Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
Biomed Pharmacother 118: 109356, 2019
業績（2018）
英文論文
Short Link N promotes disc repair in a rabbit model of disc degeneration
Fackson Mwale, Masuda K, Michael P. Grant, Laura M. Epure, Kato K, Miyazaki S, Kevin Cheng, Yamada J, Won C. Bae, Carol Muehleman, Peter J. Roughley, John Antoniou
Arthritis Research & Therapy,20:201,2018
Ristocetin induces phosphorylated-HSP27 (HSPB1) release from the platelets of type 2 DM patients: Anti-platelet agent-effect on the release
Tokuda H, Kuroyanagi G, Onuma T, Enomoto Y, Doi T, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O
Biomedical Reports,8:365-372,2018
Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling
Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Otsuka T, Kozawa O
Biomedical Reports,9:318-326,2018
HSP70 inhibitor suppresses IGF-I-Stimulated migration of osteoblasts through p44/p42 MAP kinase
Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Kuroyanagi G, Otsuka T, Kozawa O
Biomedicines,6:E109,2018
Treatment of aneurysmal bone cysts using endoscopic curettage
Aiba H, Kobayashi M, Waguri-Nagaya Y, Goto H, Mizutani J, Yamada S, Okamoto H, Nozaki M, Mitsui H, Miwa S, Kobayashi M, Endo K, Saito S, Goto T, Otsuka T
BMC Musculoskelet Disord,19:268,2018
Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model
Kuroyanagi G, Adapala NS, Yamaguchi R, Kamiya N, Deng Z, Aruwajoye O, Kutschke M, Chen E, Jo C, Ren Y, Kim HKW
Bone,116:221-231,2018
Clinical outcomes of radio-hyperthermo-chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched-pair cohort study
Aiba H, Yamada S, Mizutani J, Yamamoto N, Okamoto H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Kawai A, Yoshimura K, Tsuchiya H, Otsuka T
Cancer Med,7(4):1560-1571,2018
The janus kinase inhibitor tofacitinib inhibits TNF-α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes
Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Oguri Y, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T
Clinical and Experimental Rheumatology,36:559-567,2018
HSP70 inhibitors reduce the osteoblast migration by epidermal growth factor
Kawabata T, Otsuka T, Fujita K, Sakai G, Kim W, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H
Current molecular medicine,18:486-495,2018
Issls prize in basic science 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model
Miyazaki S, Ashish D. Diwan, Kato K, Kevin Cheng, Won C. Bae, Yang Sun, Yamada J, Carol Muehleman, Mary E. Lenz, Inoue N, Robert L. Sah, Kawakami, M Masuda K
European Spine Journal,27:739-751,2018
Association of HSP22 with mTOR in osteoblasts: regulation of TNF-α-stimulated IL-6 synthesis
Sakai G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Fujita K, Kawabata T, Kozawa O, Otsuka T
FEBS Letters,592:1202-1210,2018
Efficasy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: A multicenter, controlled, open label clinical trial
Saeki M, Tanaka K, Imatani J, Okamoto H, Watanabe K, Nakamura T, Gotani H, Ohi H, Nakamura R, Hirata H
Injury, Int. J. Care Injured,49:766-774,2018
Efficacy of radio-hyperthermo-chemotherapy as salvage therapy for recurrent or residual malignant soft tissue tumors
Aiba H, Yamada S, Mizutani J, Yamamoto N, Okamoto H, Hayashi K, Takeuchi A, Miwa S, Higuchi T, Abe K, Taniguchi Y, Tsuchiya H, Otsuka T
Int J Hyperthermia,:,2018
Comparison of stand-alone, transpsoas lateral interbody fusion at L3-4 and cranial vs transforaminal interbody fusion at L3-4 and L4-5 for the treatment of lumbar adjacent segment disease
Jain D, Verma K, Mulvihill J, Mizutani J, Tay B, Burch S, Deviren V
Int J Spine Surg,12(4):469-474,2018
(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity
Kawabata T, Otsuka T, Fujita K, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
International Jornal of Molecular Medicine,42:3149-3156,2018
Advantages of an on-the-screwhead crosslink connector for atlantoaxial fixation using the Goel/Harms technique
Mizutani J, Inada A, Kato K, Kondo A, Kainuma S, Fujita K, Yagi K, Shimamura Y, Fukuoka M, Shibamoto Y, Wada I, Otsuka T
J Clin Neurosci,50:183-189,2018
Reproducibility of acquiring ultrasonographic infant hip images by the graf method after an infant hip ultrasound training course
Shirai Y, Wakabayashi K, Wada I, Goto H, Ueki Y, Tsuchiya A, Tsuboi Y, Ha M, Otsuka T
J Med Ultrason,45(4):583-589,2018
MRI appearance in the early stage of Legg-Calve´-Perthes disease to predict lateral pillar classification: A retrospective analysis of the labral horizontalization
Shirai Y, Wakabayashi K, Wada I, Tsuboi Y, Ha M, Otsuka T
J Orthop Sci,23(1):161-167,2018
Treatment of simple bone cysts using endoscopic curettage: a case series analysis
Aiba H, Kobayashi M, Waguri-Nagaya Y, Goto H, Mizutani J, Yamada S, Okamoto H, Nozaki M, Mitsui H, Miwa S, Kobayashi M, Endo K, Saito S, Goto T, Otsuka T
J Orthop Surg Res,13(1):168,2018
Anatomical basis for arthroscopy of the proximal interphalangeal joints
Okamoto H, Sekiya I, Mizutani J, Watanabe N, Otsuka T
Journal of Hand Surgery Asian-Pacific,23(3):342-346,2018
Continuous peripheral nerve blocks for early active mobilization after hand surgery―four case reports
Otsuka T, Okamoto H (Correspondence), Mizutani J, Goto H, Sekiya I
Journal of Hand Surgery Asian-Pacific,23(3):419-423,2018
Post-operative rotator cuff integrity, based on Sugaya's classification, can reflect abduction muscle strength of the shoulder
Yoshida M, Collin P, Josseaume T, La¨dermann A, Goto H, Sugimoto K, Otsuka T
Knee Surg Sports Traumatol Arthrosc,26:161-168,2018
Preoperative radiologic predictors of successful soft tissue release surgery for hip subluxation among cerebral palsy patients: A STROBE compliant study
Ha M, Okamoto T, Fukuta T, Tsuboi Y, Shirai Y, Hattori K, Sakuma E, Wakabayashi K, Wada I, Otsuka T
Medicine (Baltimore),97(33):e11847,2018
Septic spondylodiscitis due to non-typhoidal Salmonella in a patient with rheumatoid arthritistreated with a TNF inhibitor and methotrexate
Kawaguchi Y, Waguri-Nagaya Y, Oguri Y, Nozaki M, Kobayashi M, Otsuka T
Modern Rheumatology Case Reports,28:125-129,2018
Mithramycin has inhibitory effects of gliostatin and matrix metalloproteinases expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes
Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Ikuta K, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T
Modern Rheumatology,28:495-505,2018
Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease
Watanabe T, Saito K, Ishida K, Tanabe S, Horiba M, Itamoto S, Ueki Y, Wada I, Nojima I
Neurosci Lett,674:101-105,2018
Biomechanical and anatomical validity of the short posterior arch screw
Mizutani J, Inoue N, Otsuka Y, Furuya A, Orias AAE, Otsuka T
Neurospine,16(2):347-353,2018
Global spinal alignment in cervical kyphotic deformity: The importance of head position and thoracolumbar alignment in the compensatory mechanism
Mizutani J, Verma K, Endo K, Ishii K, Abumi K, Yagi M, Hosogane N, Yang J, Tay B, Deviren V, Ames C
Neurosurgery,82(5):686-694,2018
How cervical reconstruction surgery affects global spinal alignment
Mizutani J, Strom R, Abumi K, Endo K, Ishii K, Yagi M, Tay B, Deviren V, Ames C
Neurosurgery,84(4):898-907,2018
Intraoperative blood loss error: can you ignore it?
Hirade T, Izumida M, Iguchi H, Otsuka T
Orthopaedic Proceedings,100-B:ISSUE SUPP 6,2018
Treatment of lateral tibial condylar fractures using bioactive, bioresorbable forged composites of raw particulate unsintered Hydroxyapatite/Poly-L-Lactide screws
Kuroyanagi G, Yoshihara H, Yamamoto N, Suzuki H, Yamada K, Yoshida Y, Otsuka T, Takada N
Orthopedics,41:e365-e368,2018
Preoperative evaluation of the efficacy of radio-hyperthermo-chemotherapy for soft tissue sarcoma in a case series
Aiba H, Yamada S, Mizutani J, Yamamoto N, Okamoto H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Higuchi T, Abe K, Taniguchi Y, Araki Y, Tsuchiya H, Otsuka T
PLoS One,13(4)::e0195289,2018
Spontaneous shrinkage of solitary osteochondromas
Aiba H, Yamada S, Yamamoto N, Hayashi K, Miwa S, Tsuchiya H, Otsuka T
Skeletal Radiol,47(1):61-68,2018
業績（2017）
英文論文
Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma
Miwa S, Nishida H, Tanzawa Y, Takeuchi A, Hayashi K, Yamamoto N, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
Cancer,123:1576-1584,2017
Intratendinous ganglion of the hand: two case reports occurring in the extensor digitorum communis and the flexor digitorum superficialis tendon
Senda H, Mizutani J, Okamoto H
Case Reports Plast Surg Hand Surg,4(1):9-12,2017
Resveratrol inhibits the epidermal growth Factor-induced migration of osteoblasts: the suppression of SAPK/JNK and akt
Kawabata T, Tokuda H, Fujita K, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
Cell Physiol Biochem,43(3):1025-1036,2017
Heat Shock Protein 70 negatively regulates TGF-β-Stimulated VEGF synthesis via p38 MAP kinase in osteoblasts
Sakai G, Tokuda H, Fujita K, Kainuma S, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
Cell Physiol Biochem,44:1133-1145,2017
(-)-Epigallocatechin gallate but not chlorogenic acid upregulates osteoprotegerin synthesis through regulation of bone morphogenetic protein-4 in osteoblasts
Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Experimental and Therapeutic Medicine,14:417-423,2017
Progress and role of finger joint arthroscopy
Sekiya I, Kobayashi M, Okamoto H, Otsuka T
Hand Clinics,33:819-829,2017
Current status of immunotherapy for sarcomas
Miwa S, Nishida H, Tsuchiya H
Immunotherapy,9:1331-1338,2017
Primary reattachment of avulsed skin flaps with negative pressure wound therapy in degloving injuries of the lower extremity
Sakai G, Suzuki T, Hishikawa T, Shirai Y, Kurozumi T, Shindo M
Injury,48:137-141,2017
Incretins amplify TNF-α-stimulated IL-6 synthesis in osteoblasts: Suppression of the IκB/NF-κB pathway
Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Internal Journal of Molecular Medicine,39:1053-1060,2017
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts
Kainuma S, Tokuda H, Yamamoto N, Kuroyanagi G, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
Internal Journal of Molecular Medicine,40:1057-1066,2017
Targeted disruption of NF1 in osteocytes increases FGF23 and osteoid with osteomalacia-like bone phenotype
Kamiya N, Yamaguchi R, Aruwajoye O, Kim AJ, Kuroyanagi G, Phipps M, Adapala NS, Feng JQ, Kim HK
Journal of Bone and Mineral Research,32:1716-1726,2017
Asymmetrical vertebral collapse from spinal metastasis in lower thoracic and lumbar spine
Suzuki T, Katagiri H, Noda T, Ota S, Murata H, Wasa J, Hosaka S, Shimoyama T, Takahashi M
Journal of Orthopaedic Science,22（3):405-410,2017
Comparison of quantitateive evaluation between cutaneous and transosseous inertial sensors in anterior cruciate ligament deficient knee: A cadaveric study
Murase A, Nozaki M, Kobayashi M, Goto H, Yoshida M, Yasuma S, Takenaga T, Nagaya Y, Mizutani J, Okamoto H, Iguchi H, Otsuka T
Journal of Orthopaedic Science,22(5):874-879,2017
Practical use of imaging technique for management of bone and soft tissue tumors
Miwa S, Otsuka T
Journal of Orthopaedic Science,22:391-400,2017
Anterior and posterior bands of the anterior bundle in the elbow ulnar collateral ligament: ultrasound anatomy
Yoshida M, Goto H, Takenaga T, Tsuchiya A, Sugimoto K, Musahl V, Fu F, Otsuka T
Journal of Shoulder and Elbow Surgery,26:1803-1809,2017
Left-handed skeletally mature baseball players have smaller humeral retroversion in the throwing arm than right-handed players
Takenaga T, Goto H, Sugimoto K, Tsuchiya A, Fukuyoshi M, Nakagawa H, Nozaki M, Takeuchi S, Otsuka T
Journal of Shoulder and Elbow Surgery,26(12):2187-2192,2017
Magnetic resonance imaging evaluation of the labrum to predict acetabular development in developmental dysplasia of the hip; A STROBE compliant study
Shirai Y, Wakabayashi K, Wada I, Tsuboi Y, Ha M, Otsuka T
Medicine (Baltimore),96(21):e7013,2017
Flatfoot in the contralateral foot in patients with unilateral idiopathic clubfoot treated using the foot abduction brace
Shirai Y, Wakabayashi K, Wada I, Tsuboi Y, Ha M, Otsuka T
Medicine (Baltimore),96(35):e7937,2017
Mithramycin has inhibitory effects on gliostatin and matrix metalloproteinase expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes
Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Oguri Y, Ikuta K, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T
Modern Rheumatolgy,25:1-11,2017
Attenuation of prostaglandin E1-induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
Molecular Medicine Reports,15:1847-1852,2017
Resveratrol suppresses thyroid hormone-induced osteocalcin synthesis in osteoblasts
Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Molecular Medicine Reports,16:2881-2886,2017
Amplification by (-)-epigallocatechin gallate of prostaglandin F2α-stimulated synthesis of osteoprotegerin in osteoblasts
Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Molecular Medicine Reports,16:6376-6381,2017
Suppression by HSP90 inhibitors of BMP-4-stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase
Kawabata T, Otsuka T, Fujita K, Kainuma S, Yamamoto N, Kuroyanagi G, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Molecular Medicine Reports,16:8507-8512,2017
Global spinal alignment in cervical kyphotic deformity: The importance of head position and thoraco-lumbar alignment in the compensatory mechanism
Mizutani J, Verma K, Endo K, Ishii K, Abumi K, Yagi M, Hosogane N, Yang J, Tay B, Deviren V, Ames C
Neurosurgery,doi: 10.1093/neuros/nyx288. [Epub ahead of print]:,2017
Morphological analyses of lumbar vertebra and disc with age and sex differentiation
Otsuka Yoshihisa, Suzuki N, Otsuka S, Shirai Y, Murakami S, Otsuka Yoshihiko
Osteoporosis and Sarcopenia,Vol. 1, Issue 2:134-135,2017
HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts
Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
PLoS One,12:e0177878,2017
Risk factors for postoperative deep infection in bone tumors
Miwa S, Shirai T, Yamamoto N, Hayashi K, Takeuchi A, Tada K, Kajino Y, Inatani H, Higuchi T, Abe K, Taniguchi Y, Tsuchiya H
PLoS One,9:e0187438,2017
(-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Prostaglandins & Other Lipid Mediators,128-129:27-33,2017
Surgical management of the pregnant patient with lumbar disc herniation in the latter stage of the second trimester
Hayakawa K, Mizutani J, Suzuki N, Haas C, Kondo A, Otsuka S, Fukuoka M, Otsuka T
Spine (Phila Pa 1976),42(3):E186-E189,2017
Complications associated with lateral interbody fusion: Nationwide survey of 2998 cases during the first 2 years of its use in Japan
Fujibayashi S, Kawakami N, Asazuma T, Ito M, Mizutani J, Nagashima H, Nakamura M, Sairyo K, Takemasa R, Iwasaki M
Spine (Phila Pa 1976),42(19):1478-1484,2017
Clinical application of hyperthermia to soft tissue sarcoma; result of single institution
Aiba H, Yamada S, Miwa S, Otsuka T
Thermal Med,33(4):117-127,2017
Temporary internal fixation using C1 lateral mass screw and C2 pedicle screw (Goes/Harms technique) without bone grafting for chronic atlantoaxial rotatory fixation: A case report
Matsumoto Y, Mizutani J, Suzuki N, Otsuka S, Hayakawa K, Fukuoka M, Wada I
World Neurosurgery,102:696:e1-696.e6,2017
業績（2016）
英文論文
The Combined Use of Losartan and Muscle-Derived Stem Cells Significantly Improves the Functional Recovery of Muscle in a Young Mouse Model of Contusion Injuries
Kobayashi M, Ota S, Terada A, Kawakami Y, Otsuka T, Freddie H Fu, Johnny Huard
American Journal of Sports Medicine ,44(12):3252-3261,2016
Serum- and glucocorticoid-inducible kinases in microglia
Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T
Biochem Biophys Res Commun,478(1):53-59,2016
Mechanical prophylaxis is a heparin-independent risk for anti-platelet factor 4/heparin antibody formation after orthopedic surgery
Bito S, Miyata S, Migita K, Nakamura M, Shinohara K, Sato T, Tonai T, Shimizu M, Shibata Y, Kishi K, Kubota C, Nakahara S, Mori T, Ikeda K, Ota S, Minamizaki T, Yamada S, Shiota N, Kamei M, Motokawa S
Blood,127(8):1036-1043,2016
Custom Total Hip Arthroplasty with Image-Free Screw Removing Assisted by CT Based Navigation: A Case Report
Watanabe N, Iguchi H, Kobayashi M, Otsuka T
EC Orthopaedics,3(2):277-282,2016
Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts
Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Experimental and Therapeutic Medicine,11:2042-2048,2016
AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase
Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O, Iwama T
Experimental and Therapeutic Medicine,12:1107-1112,2016
Influence of cerebral white matter lesions on the activities of daily living of older patients with mild stroke
Yamashita Y, Wada I, Horiba M, Sahashi K
Geriatr Gerontol Int,16(8):942-947,2016
Mimosine suppresses PGF2α-stimulated OPG synthesis in osteoblasts
Kuroyanagi G, Otsuka T, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Internal Journal of Molecular Medicine,37:533-541,2016
Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients
Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O
Internal Journal of Molecular Sciences,17:E737,2016
Randomized Study of Direct Anterior Approach versus Posterior Approach for Bipolar Hemiarthroplasty of the Hip
Aiba H, Watanabe N, Nishimori Y, Onogi H, Oguri Y, Yamagami T, Okamoto H, Sakurai H, Otsuka T
Jacobs Journal of Orthopedics and Rheumatology,1(2):10,2016
Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts
Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima-Nishiwaki R, Fujita K, Kozawa O, Otsuka T
Molecular and Cellular Endocrinology,436:1-9,2016
Regulation by AMP-activated protein kinase of the PGE2-induced osteoprotegerin synthesis in osteoblasts
Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Molecular Medicine Reports,13:3363-3369,2016
Prospective randomised study of direct anterior approach versus posterior approach for bipolar hemiarthroplasty of the hip
Watanabe N, Aiba H, Sagara G, Yamagami T, Nishimori Y, Waseda Y, Oguri Y, Onogi H, Sakurai H, Otsuka T
Orthopaedic Proceedings,98-B SUPP 4:123,2016
Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase
Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T
PLoS One,11:e0149077,2016
Surgical Management of the Pregnant Patient with Lumbar Disc Herniation in the Latter Stage of the Second Trimester
Hayakawa K, Mizutani J, Suzuki N, Haas C, Kondo A, Otsuka S, Fukuoka M, Otsuka T
Spine,e-pub:,2016
CXCR4+CD45- cells are niche forming for osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 signaling pathways in bone marrow
Goto Y, Aoyama M, Sekiya T, Waguri-Nagaya Y, Miyazawa K, Asai K, Goto S.
Stem Cells,34:2733-2743,2016
Prediction of skeletal-related events in patients with non-small cell lung cancer
Aiba H, Kimura T, Yamagami T, Watanabe N, Sakurai H, Kimura H, Shimozaki S, Yamada S, Otsuka T
Support Care Cancer,24(8):3361-7,2016